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Vendredi 26 novembre 2021 / IUSTI

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Séminaire IUSTI

Mechanical properties of fiber networks

Orateur : Mehdi Bouzid – CR 3SR Lab, Grenoble

Abstract : Gels of fibrous biopolymers are ubiquitous within cells and their rigidity is crucial for their function [1]. Our current understanding of their elastic response is usually understood as an interplay between the bending and stretching of their filaments [2]. This point of view however fails when applied to the weakly coordinated branched actin networks found throughout the cell [3, 4]. Through experiments and theory, we show that their elasticity crucially involves reversible entanglements between their filaments. Additional entanglements may get locked in during network growth, setting the final properties of the network [5]. These properties could be key to understanding how moving cells dynamically adapt their cytoskeleton to their environment.

References :
[1] G Letort, H Ennomani, L Gressin, M Théry, and L Blanchoin. Dynamic reorganization of the actin cytoskeleton. F1000Research, 4, 2015.
[2] C. P Broedersz, X Mao, T C Lubensky, and F. C MacKintosh. Criticality and isostaticity in fibre networks. Nature Physics, 7(12):983, 2011.
[3] P Bauer, J Tavacoli, T Pujol, J Planade, J Heuvingh, and O Du Roure. A new method to measure mechanics and dynamic assembly of branched actin networks. Scientific reports, 7(1):15688, 2017.
[4] Antoine Allard, Mehdi Bouzid, Timo Betz, Camille Simon, Majdouline Abou-Ghali, Joel Lemiere, Fabrice Valentino, John Manzi, Francoise Brochard-Wyart, Karine Guevorkian, et al. Actin modulates shape and mechanics of tubular membranes. Science Advances, 6(17):eaaz3050, 2020.
[5] M Bouzid, C Valencia Gallardo, L Koehler, G Foffi, J Heuvingh, O du Roure, and M Lenz. Elasticity from entanglements in branched actin. In preparation.

Date et lieu : vendredi 26 novembre 2021 à 11h00, salle 250 IUSTI

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